Transcription activation by a variety of AraC/XylS family activators does not depend on the class II-specific activation determinant in the N-terminal domain of the RNA polymerase alpha subunit.

نویسندگان

  • S M Egan
  • A J Pease
  • J Lang
  • X Li
  • V Rao
  • W K Gillette
  • R Ruiz
  • J L Ramos
  • R E Wolf
چکیده

The N-terminal domain of the RNA polymerase alpha subunit (alpha-NTD) was tested for a role in transcription activation by a variety of AraC/XylS family members. Based on substitutions at residues 162 to 165 and an extensive genetic screen we conclude that alpha-NTD is not an activation target for these activators.

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عنوان ژورنال:
  • Journal of bacteriology

دوره 182 24  شماره 

صفحات  -

تاریخ انتشار 2000